Early-Stage Metastasis Requires Mdm2 and Not p53 Gain of Function
نویسندگان
چکیده
منابع مشابه
Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis
The tumour suppressor p53 is frequently mutated in tumours. Mutant p53 (Mutp53) proteins often gain new activities in promoting tumorigenesis, defined as gain-of-function (GOF). Mutp53 can accumulate to high levels in tumours, which promotes mutp53 GOF in tumorigenesis. The mechanism of mutp53 accumulation is poorly understood. Here we find that MDM2 isoforms promote mutp53 accumulation in tumo...
متن کاملMutant p53 gain-of-function in cancer.
In its wild-type form, p53 is a major tumor suppressor whose function is critical for protection against cancer. Many human tumors carry missense mutations in the TP53 gene, encoding p53. Typically, the affected tumor cells accumulate excessive amounts of the mutant p53 protein. Various lines of evidence indicate that, in addition to abrogating the tumor suppressor functions of wild-type p53, t...
متن کاملThe MDM2-p53 interaction.
Activation of the p53 protein protects the organism against the propagation of cells that carry damaged DNA with potentially oncogenic mutations. MDM2, a p53-specific E3 ubiquitin ligase, is the principal cellular antagonist of p53, acting to limit the p53 growth-suppressive function in unstressed cells. In unstressed cells, MDM2 constantly monoubiquitinates p53 and thus is the critical step in...
متن کاملp53-independent functions of MDM2.
The tumor suppressor p53 is inactivated by overexpression of MDM2 in about 10% of human tumors. However, p53 is inactivated by other mechanisms in the majority of tumors, raising the possibility that MDM2 may be irrelevant to transformation in most cases. However, MDM2 has been reported to have p53-independent functions, in cell cycle control, differentiation, cell fate determination, DNA repai...
متن کاملpage translation and stage translation of drama texts
نمایشنامه به پیروی از ماهیت دوگانه اش، کارکردی دوگانه به خود می گیرد، بدین معنا که در هر دو نظام ادبی و تئاتری می تواند کارکردی مختص به خود یابد. هدف از انجام این پژوهش یافتن تفاوت ها میان ترجمه صفحه و ترجمه صحنه است.. پرسش مطرح شده عبارتست از: بر اساس مدل ارائه شده توسط لدوسر (1995)، تفاوت های ترجمه صفحه و ترجمه صحنه در چیست؟ یافته های این پژوهش حاکی از آن است که ترجمه صفحه به نمایشنامه ا...
ذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Cancer Research
سال: 2017
ISSN: 1541-7786,1557-3125
DOI: 10.1158/1541-7786.mcr-17-0174